Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent studies have established critical functions for these tiny RNAs in almost every facet of cardiac development and disease. The realization that miRNAs are amenable to therapeutic manipulation has also generated considerable interest in the potential of miRNA-based drugs for the treatment of a number of human diseases, including cardiovascular disease. In the present review, I discuss well-established and emerging roles of miRNAs in cardiac development, their relevance to congenital heart disease and unresolved questions in the field for future investigation, as well as emerging therapeutic possibilities for cardiac regeneration.
Skip Nav Destination
Review Article| April 26 2013
microRNAs in cardiac development and regeneration
Enzo R. Porrello
1School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
Correspondence: Dr Enzo R. Porrello (email email@example.com).
Search for other works by this author on:
Clin Sci (Lond) (2013) 125 (4): 151–166.
January 03 2013
February 11 2013
February 15 2013
Enzo R. Porrello; microRNAs in cardiac development and regeneration. Clin Sci (Lond) 1 August 2013; 125 (4): 151–166. doi: https://doi.org/10.1042/CS20130011
Download citation file:
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your InstitutionSign in via your Institution
Get Access To This Article
Buy This Article