The paper by Wang et al. [1] published in Clinical Science provided for highly interesting reading. Interestingly, recent data confirms that bafilomycin A1 decreases tumour growth in a number of systemic malignancies. For instance, it decreases growth in colonic malignancies. It mediates its antineoplastic effects by attenuating lysosomal acidification within the cancerous cells. At the same time, p38 phosphorylation is markedly attenuated [2] and mitochondrial uncoupling is typically augmented. On the other hand, caspase 7 and caspase 8 cleavage is accentuated. As a result, macro-autophagy is markedly inhibited, resulting in G0/G1-phase arrest. Bafilomycin A1 administration also has a negative impact on HIF-1α (hypoxia-inducible factor-1α) cleavage [3] and subsequent accentuation of HIF-1α levels. This results in p21 induction and consequent cell-cycle arrest. JNK (c-Jun N-terminal kinase) phosphorylation is also decreased significantly, whereas p21 is typically up-regulated. The ultimate result is augmented...
Skip Nav Destination
Article navigation
Correspondence|
May 01 2013
Bafilomycin A1 and its attenuating effect on tumour growth in systemic malignancies, especially gastrointestinal malignancies
Shailendra Kapoor
1University of Illinois at Chicago, Chicago, IL 60612, U.S.A.
Correspondence: Dr Shailendra Kapoor (email shailendrakapoor@yahoo.com).
Search for other works by this author on:
Clin Sci (Lond) (2013) 125 (4): 219.
Article history
Received:
February 04 2013
Accepted:
March 12 2013
Accepted Manuscript online:
March 12 2013
Citation
Shailendra Kapoor; Bafilomycin A1 and its attenuating effect on tumour growth in systemic malignancies, especially gastrointestinal malignancies. Clin Sci (Lond) 1 August 2013; 125 (4): 219. doi: https://doi.org/10.1042/CS20130057
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.