The recently discovered myokine irisin has been implicated in several observational studies as a potential therapeutic target for obesity-related diseases. However, no information is available as to the heritability of this hormone. The present study aims to fill this gap. A total of 120 families (n=254; 121 adults and 133 children) were included in the study taken from the Riyadh Biomarkers Research Program cohort. Information gathered include anthropometrics, and glycaemic, lipid and adipocytokine profiles. Irisin was measured using ELISA. Examining heritability between mother and offspring, the most significant heritable traits in sons included irisin (P=1.6×10−5), systolic blood pressure (P=3.6×10−4), total cholesterol (P=3.5×10−7) and LDL (low-density lipoprotein)-cholesterol (P=1.2×10−6). Heritable traits between mother and daughter again included irisin (P<0.002), as well as anthropometric associations such as waist (P<0.01) and hip (P<0.005) circumference and blood pressure (P<0.002); biochemically, principal associations were observed with HDL (high-density lipoprotein)-cholesterol (P<0.04) and TNF-α (tumour necrosis factor-α) (P<0.002). HDL-cholesterol was the single most significant predictor for irisin levels in adults, explaining 17% of the variance, whereas in children AngII (angiotensin II) was the most significant predictor of irisin levels, explaining 19% of the variance (P=0.003). Circulating irisin appears to be maternally inherited and is predicted by HDL-cholesterol in adults and AngII in children, both factors influenced by energy expenditure and regulation. Taken together, these findings suggest a significant role of irisin in energy-generating processes.
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Research Article|
February 26 2014
Maternal inheritance of circulating irisin in humans
Nasser M. Al-Daghri;
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Correspondence: Dr Nasser M. Al-Daghri ([email protected]).
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Omar S. Al-Attas;
Omar S. Al-Attas
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
‡Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia
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Majed S. Alokail;
Majed S. Alokail
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
‡Center of Excellence in Biotechnology Research, King Saud University, Riyadh, Saudi Arabia
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Khalid M. Alkharfy;
Khalid M. Alkharfy
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
§Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
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Mansour Yousef;
Mansour Yousef
∥Health Affairs for Riyadh Region, Ministry of Health, 11176 Riyadh, Saudi Arabia
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Benjamin Vinodson;
Benjamin Vinodson
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
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Osama E. Amer;
Osama E. Amer
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
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Abdullah M. Alnaami;
Abdullah M. Alnaami
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
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Shaun Sabico;
Shaun Sabico
*Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
†Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
¶Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry CV2 2DX, U.K.
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Gyanendra Tripathi;
Gyanendra Tripathi
¶Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry CV2 2DX, U.K.
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Milan K. Piya;
Milan K. Piya
¶Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry CV2 2DX, U.K.
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Philip G. McTernan;
Philip G. McTernan
¶Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, Coventry CV2 2DX, U.K.
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George P. Chrousos
George P. Chrousos
**First Department of Pediatrics, Athens University Medical School, Athens 11527, Greece
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Publisher: Portland Press Ltd
Received:
July 29 2013
Revision Received:
December 13 2013
Accepted:
January 08 2014
Accepted Manuscript online:
January 08 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2014 Biochemical Society
2014
Clin Sci (Lond) (2014) 126 (12): 837–844.
Article history
Received:
July 29 2013
Revision Received:
December 13 2013
Accepted:
January 08 2014
Accepted Manuscript online:
January 08 2014
Citation
Nasser M. Al-Daghri, Omar S. Al-Attas, Majed S. Alokail, Khalid M. Alkharfy, Mansour Yousef, Benjamin Vinodson, Osama E. Amer, Abdullah M. Alnaami, Shaun Sabico, Gyanendra Tripathi, Milan K. Piya, Philip G. McTernan, George P. Chrousos; Maternal inheritance of circulating irisin in humans. Clin Sci (Lond) 1 June 2014; 126 (12): 837–844. doi: https://doi.org/10.1042/CS20130426
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