Physiological and pathological roles for small non-encoding miRNAs (microRNAs) in the cardiovascular system have recently emerged and are now widely studied. The discovery of widespread functions of miRNAs has increased the complexity of gene-regulatory processes and networks in both the cardiovascular system and cardiovascular diseases. Indeed, it has recently been shown that miRNAs are implicated in the regulation of many of the steps leading to the development of cardiovascular disease. These findings represent novel aspects in miRNA biology and, therefore, our understanding of the role of these miRNAs during the pathogenesis of cardiovascular disease is critical for the development of novel therapies and diagnostic interventions. The present review will focus on understanding how miRNAs are involved in the onset and development of cardiovascular diseases.
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Review Article|
October 01 2013
microRNAs in the onset and development of cardiovascular disease
Kasey C. Vickers;
Kasey C. Vickers
*Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A.
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Kerry-Anne Rye;
Kerry-Anne Rye
†Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
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Fatiha Tabet
†Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
Correspondence: Dr Fatiha Tabet (email [email protected] or [email protected]).
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Publisher: Portland Press Ltd
Received:
April 24 2013
Revision Received:
July 11 2013
Accepted:
August 12 2013
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2014 Biochemical Society
2014
Clin Sci (Lond) (2014) 126 (3): 183–194.
Article history
Received:
April 24 2013
Revision Received:
July 11 2013
Accepted:
August 12 2013
Citation
Kasey C. Vickers, Kerry-Anne Rye, Fatiha Tabet; microRNAs in the onset and development of cardiovascular disease. Clin Sci (Lond) 1 February 2014; 126 (3): 183–194. doi: https://doi.org/10.1042/CS20130203
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