A decade ago, the (P)RR [(pro)renin receptor] was discovered and depicted as a potential activator of the tissue renin–angiotensin system. For this reason, the role of the (P)RR in cardiovascular diseases and diabetes has been particularly studied. However, the discovery of embryonic lethality after (P)RR gene deletion in mouse and zebrafish paved the way for additional roles of (P)RR in cell homoeostasis. Indeed, the (P)RR has been shown to associate with vacuolar H+-ATPase, hence its other name ATP6ap2. Developmental studies in Xenopus and Drosophila have revealed an essential role of this association to promote the canonical and non-canonical Wnt signalling pathways, whereas studies with tissue-specific gene deletion have pointed out a role in autophagy. The present review aims to summarize recent findings on the cellular functions of (P)RR emerging from various mutated and transgenic animal models.
Review Article| December 17 2013
(Pro)renin receptor and V-ATPase: from Drosophila to humans
*Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, D-13125 Berlin-Buch, Germany
†Charité-University Medicine, Charitéplatz 1, 10117 Berlin, Germany
‡Institute for Biology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
Correspondence: Professor Michael Bader (email@example.com).
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Anthony Rousselle, Gabin Sihn, Martijn Rotteveel, Michael Bader; (Pro)renin receptor and V-ATPase: from Drosophila to humans. Clin Sci (Lond) 1 April 2014; 126 (8): 529–536. doi: https://doi.org/10.1042/CS20130307
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