Abnormal angiogenesis in liver cirrhosis often leads to severe complications such as variceal haemorrhage and encephalopathy. Furthermore, splanchnic angiogenesis elevates portal pressure, in which angiogenic factors play pivotal roles. GTP (green tea polyphenol) extracted from Camellia sinensis has anti-angiogenic properties, but the effects on the parameters described above in cirrhosis have not been investigated. The aim of the present study was to determine the effects of GTP in cirrhosis and to investigate the underlying mechanism. Liver cirrhosis was induced in Spraque–Dawley rats by common BDL (bile duct ligation). They randomly received GTP or DW (distilled water, vehicle) for 28 days, then haemodynamic parameters, portosystemic shunting, mesenteric window vascular density, intrahepatic angiogenesis, liver fibrosis, plasma VEGF (vascular endothelial growth factor) concentration, mesenteric angiogenic factor and receptor protein expression, and serum and mesenteric oxidative stress parameters were assessed. Compared with the DW group, GTP significantly decreased portosystemic shunting, liver fibrosis, intrahepatic angiogenesis, mesenteric window vascular density, VEGF concentration and down-regulated the mesenteric HIF (hypoxia-inducible factor)-1α, VEGF and phospho-Akt expression. In conclusion, GTP ameliorates the severity of portosystemic shunting and mesenteric angiogenesis via the suppression of HIF-1α, Akt activation and VEGF. GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis.
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Research Article|
January 14 2014
Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis
Shao-Jung Hsu;
Shao-Jung Hsu
*Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
‡Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
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Sun-Sang Wang;
Sun-Sang Wang
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
§Department of Medical Affair and Planning, Taipei Veterans General Hospital, Taipei, Taiwan
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I-Fang Hsin;
I-Fang Hsin
*Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan
∥Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei, Taiwan
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Fa-Yauh Lee;
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
‡Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
Correspondence: Professor Fa-Yauh Lee (email [email protected]) and Associate Professor Hui-Chun Huang (email [email protected]).
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Hui-Chun Huang;
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
‡Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
Correspondence: Professor Fa-Yauh Lee (email [email protected]) and Associate Professor Hui-Chun Huang (email [email protected]).
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Teh-Ia Huo;
Teh-Ia Huo
*Institute of Pharmacology, National Yang-Ming University School of Medicine, Taipei, Taiwan
‡Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
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Wen-Shin Lee;
Wen-Shin Lee
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
¶General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Han-Chieh Lin;
Han-Chieh Lin
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
‡Division of Gastroenterology, Taipei Veterans General Hospital, Taipei, Taiwan
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Shou-Dong Lee
Shou-Dong Lee
†Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
**Division of Gastroenterology, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan
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Publisher: Portland Press Ltd
Received:
May 01 2013
Revision Received:
September 19 2013
Accepted:
September 25 2013
Accepted Manuscript online:
September 25 2013
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2014 Biochemical Society
2014
Clin Sci (Lond) (2014) 126 (9): 633–644.
Article history
Received:
May 01 2013
Revision Received:
September 19 2013
Accepted:
September 25 2013
Accepted Manuscript online:
September 25 2013
Connected Content
This is a commentary on:
Is it tea time for portal hypertension?
Citation
Shao-Jung Hsu, Sun-Sang Wang, I-Fang Hsin, Fa-Yauh Lee, Hui-Chun Huang, Teh-Ia Huo, Wen-Shin Lee, Han-Chieh Lin, Shou-Dong Lee; Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis. Clin Sci (Lond) 1 May 2014; 126 (9): 633–644. doi: https://doi.org/10.1042/CS20130215
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