Integrin-linked kinase predominantly localizes at focal adhesions to regulate actin cytoskeletal dynamics, including cell migration and matrix remodelling. Although recent studies have suggested both physiological and pathophysiological roles of integrin-linked kinase in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science, Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice with conditional deficiency of integrin-linked kinase, which were associated with suppression of nuclear factor κB activation and reactive oxygen species generation but not hypertension. The significance, potential mechanisms and future direction are presented and discussed in this Commentary.
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July 2014
Commentary|
March 10 2014
Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?
Takashi Obama
;
Takashi Obama
*Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
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Satoru Eguchi
*Cardiovascular Research Center, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, U.S.A.
Correspondence: Professor Satoru Eguchi (email seguchi@temple.edu).
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Clin Sci (Lond) (2014) 127 (1): 15–17.
Article history
Received:
January 28 2014
Accepted:
January 31 2014
Accepted Manuscript online:
January 31 2014
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A commentary has been published:
Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation
Citation
Takashi Obama, Satoru Eguchi; Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?. Clin Sci (Lond) 1 July 2014; 127 (1): 15–17. doi: https://doi.org/10.1042/CS20140081
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