Aseptic loosening as a result of wear debris is considered to be the main cause of long-term implant failure in orthopaedic surgery and improved biomaterials for bearing surfaces decreases significantly the release of micrometric wear particles. Increasingly, in-depth knowledge of osteoimmunology highlights the role of nanoparticles and ions released from some of these new bearing couples, opening up a new era in the comprehension of aseptic loosening. Mouse models have been essential in the progress made in the early comprehension of pathophysiology and in testing new therapeutic agents for particle-induced osteolysis. However, despite this encouraging progress, there is still no valid clinical alternative to revision surgery. The present review provides an update of the most commonly used bearing couples, the current concepts regarding particle–cell interactions and the approaches used to study the biology of periprosthetic osteolysis. It also discusses the contribution and future challenges of mouse models for successful translation of the preclinical progress into clinical applications.
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Review Article|
May 07 2014
Orthopaedic implant failure: aseptic implant loosening–the contribution and future challenges of mouse models in translational research
Luis Alberto Cordova;
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
‡Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Chile–CONICYT, Santiago, Chile
Correspondence: Dr Luis Alberto Córdova (email [email protected]).
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Verena Stresing;
Verena Stresing
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
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Bérengère Gobin;
Bérengère Gobin
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
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Philippe Rosset;
Philippe Rosset
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
§Tours University Hospital and University François Rabelais, 60 rue du Plat D’Etain, 37020 Tours, France
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Norbert Passuti;
Norbert Passuti
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
¶Nantes University Hospital, 85 Rue Saint-Jacques Nantes Cedex 1, France
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François Gouin;
François Gouin
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
¶Nantes University Hospital, 85 Rue Saint-Jacques Nantes Cedex 1, France
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Valérie Trichet;
Valérie Trichet
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
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Pierre Layrolle;
Pierre Layrolle
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
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Dominique Heymann
Dominique Heymann
*INSERM, UMR 957, Faculty of Medicine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
†Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, University of Nantes, Nantes Atlantique Universities, 1 rue Gaston Veil, 44035 Nantes cedex 1, France
¶Nantes University Hospital, 85 Rue Saint-Jacques Nantes Cedex 1, France
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Publisher: Portland Press Ltd
Received:
July 01 2013
Revision Received:
November 11 2013
Accepted:
January 30 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2014 Biochemical Society
2014
Clin Sci (Lond) (2014) 127 (5): 277–293.
Article history
Received:
July 01 2013
Revision Received:
November 11 2013
Accepted:
January 30 2014
Citation
Luis Alberto Cordova, Verena Stresing, Bérengère Gobin, Philippe Rosset, Norbert Passuti, François Gouin, Valérie Trichet, Pierre Layrolle, Dominique Heymann; Orthopaedic implant failure: aseptic implant loosening–the contribution and future challenges of mouse models in translational research. Clin Sci (Lond) 1 September 2014; 127 (5): 277–293. doi: https://doi.org/10.1042/CS20130338
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