Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to the HMG (high-mobility group) protein family, is one of the most modified proteins in the mammalian proteome. Although very little is known about the biological roles of NUCKS, emerging clinical evidence suggests that this protein can be a biomarker and therapeutic target in various human ailments, including several types of cancer. An inverse correlation between NUCKS protein levels and body mass index in humans has also been observed. Depletion of NUCKS in mice has been reported to lead to obesity and impaired glucose homoeostasis. Genome-wide genomic and proteomic approaches have revealed that NUCKS is a chromatin regulator that affects transcription. The time is now ripe for further understanding of the role of this novel biomarker of cancer and the metabolic syndrome, and how its sundry modifications can affect its function. Such studies could reveal how NUCKS could be a link between physiological cues and human ailments.
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Review Article|
March 10 2015
NUCKS: a potential biomarker in cancer and metabolic disease
Beiying Qiu;
Beiying Qiu
*Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 138673, Singapore
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Weiping Han;
†Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 138667, Singapore
‡Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
Correspondence: Dr Weiping Han (email [email protected]) or Dr Vinay Tergaonkar (email [email protected]).
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Vinay Tergaonkar
*Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 138673, Singapore
‡Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
Correspondence: Dr Weiping Han (email [email protected]) or Dr Vinay Tergaonkar (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 15 2014
Revision Received:
December 01 2014
Accepted:
December 19 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2015 Biochemical Society
2015
Clin Sci (Lond) (2015) 128 (10): 715–721.
Article history
Received:
October 15 2014
Revision Received:
December 01 2014
Accepted:
December 19 2014
Citation
Beiying Qiu, Weiping Han, Vinay Tergaonkar; NUCKS: a potential biomarker in cancer and metabolic disease. Clin Sci (Lond) 1 May 2015; 128 (10): 715–721. doi: https://doi.org/10.1042/CS20140656
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