This study has demonstrated for the first time that cryopreservation of primary immune cells modified their metabolism in a time-dependent fashion, indicated by attenuated aerobic respiration and enhanced glycolytic activity. Measurements were recorded using the Seahorse XFe96 extracellular flux analyser.
The impact of cryopreservation on human peripheral blood leucocyte bioenergetics
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Kevin N. Keane, Emily K. Calton, Vinicius F. Cruzat, Mario J. Soares, Philip Newsholme; The impact of cryopreservation on human peripheral blood leucocyte bioenergetics. Clin Sci (Lond) 1 May 2015; 128 (10): 723–733. doi: https://doi.org/10.1042/CS20140725
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