miRNAs are regulators of gene expression in diverse biological and pathological courses in life. Their discovery may be considered one of the most important steps in the story of modern biology. miRNAs are packed within exosomes and released by cells for cellular communications; they are present in bodily fluids. Their study opens the way for understanding the pathogenetic mechanisms of many diseases; furthermore, as potential candidate biomarkers, they can be measured in bodily fluids for non-invasive monitoring of disease outcomes. The present review highlights recent advances in the role of miRNAs in the pathogenesis of primary and secondary glomerulonephritides such as IgA nephropathy, focal segmental glomerular sclerosis, lupus nephritis and diabetic nephropathy. The identification of reciprocal expression of miRNAs and their target genes provides the molecular basis for additional information on the pathogenetic mechanisms of kidney diseases. Finally, recent findings demonstrate that miRNAs can be considered as potential targets for novel drugs.
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Review Article|
March 19 2015
microRNAs in glomerular diseases from pathophysiology to potential treatment target
Francesco P. Schena;
*C.A.R.S.O. Consortium, University of Bari, Strada Prov. le Valenzano-Casamassima Km 3, 70100 Valenzano (Ba), Italy
Correspondence: Dr Francesco Schena (email [email protected]).
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Fabio Sallustio;
Fabio Sallustio
*C.A.R.S.O. Consortium, University of Bari, Strada Prov. le Valenzano-Casamassima Km 3, 70100 Valenzano (Ba), Italy
†Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
‡Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (DiSTeBA), Università del Salento, S.P. 6, Lecce–Monteroni, 73100 Lecce, Italy
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Grazia Serino
Grazia Serino
*C.A.R.S.O. Consortium, University of Bari, Strada Prov. le Valenzano-Casamassima Km 3, 70100 Valenzano (Ba), Italy
†Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
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Publisher: Portland Press Ltd
Received:
November 10 2014
Revision Received:
December 23 2014
Accepted:
January 09 2015
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2015 Biochemical Society
2015
Clin Sci (Lond) (2015) 128 (11): 775–788.
Article history
Received:
November 10 2014
Revision Received:
December 23 2014
Accepted:
January 09 2015
Citation
Francesco P. Schena, Fabio Sallustio, Grazia Serino; microRNAs in glomerular diseases from pathophysiology to potential treatment target. Clin Sci (Lond) 1 June 2015; 128 (11): 775–788. doi: https://doi.org/10.1042/CS20140733
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