The incidence of stroke and myocardial infarction increases in aged patients and it is associated with an adverse outcome. Considering the aging population and the increasing incidence of cardiovascular disease, the prediction for population well-being and health economics is daunting. Accordingly, there is an unmet need to focus on fundamental processes underlying vascular aging. A better understanding of the pathways leading to arterial aging may contribute to design mechanism-based therapeutic approaches to prevent or attenuate features of vascular senescence. In the present review, we discuss advances in the pathophysiology of age-related vascular dysfunction including nitric oxide signalling, dysregulation of oxidant/inflammatory genes, epigenetic modifications and mechanisms of vascular calcification as well as insights into vascular repair. Such an overview highlights attractive molecular targets for the prevention of age-driven vascular disease.
Skip Nav Destination
Article navigation
January 2015
-
Cover Image
Cover Image
- PDF Icon PDF LinkTable of Contents
Review Article|
September 05 2014
Molecular pathways of arterial aging
Francesco Paneni;
Francesco Paneni
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Search for other works by this author on:
Sarah Costantino;
Sarah Costantino
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Search for other works by this author on:
Francesco Cosentino
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Correspondence: Professor Francesco Cosentino (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
May 13 2014
Revision Received:
June 27 2014
Accepted:
July 22 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2015 Biochemical Society
2015
Clin Sci (Lond) (2015) 128 (2): 69–79.
Article history
Received:
May 13 2014
Revision Received:
June 27 2014
Accepted:
July 22 2014
Citation
Francesco Paneni, Sarah Costantino, Francesco Cosentino; Molecular pathways of arterial aging. Clin Sci (Lond) 1 January 2015; 128 (2): 69–79. doi: https://doi.org/10.1042/CS20140302
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |