Determining the role of NADPH oxidases in the context of virus infection is an emerging area of research and our knowledge is still sparse. The expression of various isoforms of NOX/DUOX (NADPH oxidase/dual oxidase) in the epithelial cells (ECs) lining the respiratory tract renders them primary sites from which to orchestrate the host defence against respiratory viruses. Accumulating evidence reveals distinct facets of the involvement of NOX/DUOX in host antiviral and pro-inflammatory responses and in the control of the epithelial barrier integrity, with individual isoforms mediating co-operative, but surprisingly also opposing, functions. Although in vivo studies in mice are in line with some of these observations, a complete understanding of the specific functions of epithelial NOX/DUOX awaits lung epithelial-specific conditional knockout mice. The goal of the present review is to summarize our current knowledge of the role of individual NOX/DUOX isoforms expressed in the lung epithelium in the context of respiratory virus infections so as to highlight potential opportunities for therapeutic intervention.
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Review Article|
November 28 2014
Lung epithelial NOX/DUOX and respiratory virus infections
Nathalie Grandvaux;
*CRCHUM–Centre Hospitalier de l’Université de Montréal, Montréal, Quebec, Canada, H2X 0A9
†Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Quebec, Canada, H3C 3J7
Correspondence: Dr Nathalie Grandvaux (email [email protected]).
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Mélissa Mariani;
Mélissa Mariani
*CRCHUM–Centre Hospitalier de l’Université de Montréal, Montréal, Quebec, Canada, H2X 0A9
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Karin Fink
Karin Fink
*CRCHUM–Centre Hospitalier de l’Université de Montréal, Montréal, Quebec, Canada, H2X 0A9
†Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Quebec, Canada, H3C 3J7
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Publisher: Portland Press Ltd
Received:
May 23 2014
Revision Received:
October 06 2014
Accepted:
October 07 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2015 Biochemical Society
2015
Clin Sci (Lond) (2015) 128 (6): 337–347.
Article history
Received:
May 23 2014
Revision Received:
October 06 2014
Accepted:
October 07 2014
Citation
Nathalie Grandvaux, Mélissa Mariani, Karin Fink; Lung epithelial NOX/DUOX and respiratory virus infections. Clin Sci (Lond) 1 March 2015; 128 (6): 337–347. doi: https://doi.org/10.1042/CS20140321
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