Plasma free fatty acids (non-esterified fatty acids) increase in the first hour of the onset of acute myocardial ischaemia. This results from catecholamine stimulation of adipose tissue lipolysis. It can lead to a metabolic crisis in the injured myocardium with the development of ventricular arrhythmias and increased early mortality. Preconditioning, β-adrenergic blockade and glucose–insulin–potassium are possible therapeutic approaches, but anti-lipolytic agents, such as some nicotinic acid derivatives, can reduce plasma free fatty acid concentrations within minutes and have untried potential. A clinical trial of their effectiveness is needed from the first moment when a patient with an acute coronary syndrome is seen by paramedics.
Review Article| November 28 2014
Fatty acids and the risk of death during acute myocardial ischaemia
- Views Icon Views
- Share Icon Share
- Cite Icon Cite
Michael F. Oliver; Fatty acids and the risk of death during acute myocardial ischaemia. Clin Sci (Lond) 1 March 2015; 128 (6): 349–355. doi: https://doi.org/10.1042/CS20140404
Download citation file: