Inhibition of epidermal growth factor receptor (EGFR) activation protected mice from abdominal aortic aneurysm (AAA), which is probably due to suppression of vascular endoplasmic reticulum (ER) stress. Since the signal was confirmed in humans, EGFR may provide a novel therapeutic target for aortic aneurysm.
Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model
- Views Icon Views
- Share Icon Share
Takashi Obama, Toshiyuki Tsuji, Tomonori Kobayashi, Yamato Fukuda, Takehiko Takayanagi, Yoshinori Taro, Tatsuo Kawai, Steven J. Forrester, Katherine J. Elliott, Eric Choi, Alan Daugherty, Victor Rizzo, Satoru Eguchi; Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model. Clin Sci (Lond) 1 May 2015; 128 (9): 559–565. doi: https://doi.org/10.1042/CS20140696
Download citation file: