Neutrophil gelatinase-associated lipocalin (NGAL) has recently become established as an important contributor to the pathophysiology of cardiovascular disease. Accordingly, it is now viewed as an attractive candidate as a biomarker for various disease states, and in particular has recently become regarded as one of the best diagnostic biomarkers available for acute kidney injury. Nevertheless, the precise physiological effects of NGAL on the heart and the significance of their alterations during the development of heart failure are only now beginning to be characterized. Furthermore, the mechanisms via which NGAL mediates its effects are unclear because there is no conventional receptor signalling pathway. Instead, previous work suggests that regulation of iron metabolism could represent an important mechanism of NGAL action, with wide-ranging consequences spanning metabolic and cardiovascular diseases to host defence against bacterial infection. In the present review, we summarize rapidly emerging evidence for the role of NGAL in regulating heart failure. In particular, we focus on iron transport as a mechanism of NGAL action and discuss this in the context of the existing strong associations between iron overload and iron deficiency with cardiomyopathy.
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Review Article|
August 28 2015
Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy
Yee Kwan Chan;
Yee Kwan Chan
*Department of Biology, York University, Toronto, Ontario, Canada
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Hye Kyoung Sung;
Hye Kyoung Sung
*Department of Biology, York University, Toronto, Ontario, Canada
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Gary Sweeney
*Department of Biology, York University, Toronto, Ontario, Canada
Correspondence: Dr Gary Sweeney ([email protected]).
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Publisher: Portland Press Ltd
Received:
January 26 2015
Revision Received:
June 08 2015
Accepted:
July 14 2015
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2015 Authors; published by Portland Press Limited
2015
Clin Sci (Lond) (2015) 129 (10): 851–862.
Article history
Received:
January 26 2015
Revision Received:
June 08 2015
Accepted:
July 14 2015
Citation
Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney; Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy. Clin Sci (Lond) 1 November 2015; 129 (10): 851–862. doi: https://doi.org/10.1042/CS20150075
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