EEF1D (eukaryotic translation elongation factor 1δ) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are recognized, EEF1D expression was found to be unbalanced in tumours. In the present study, we demonstrate the overexpression of EEF1D in OSCC (oral squamous cell carcinoma), and revealed that EEF1D and protein interaction partners promote the activation of cyclin D1 and vimentin proteins. EEF1D knockdown in OSCC reduced cell proliferation and induced EMT (epithelial–mesenchymal transition) phenotypes, including cell invasion. Taken together, these results define EEF1D as a critical inducer of OSCC proliferation and EMT.
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May 2016
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Paraffin section of knee joint from CIA mouse model. Safranin-O/fast green staining showed significant cartilage degeneration and bone erosion in femorotibial joint. For further details see pp. 667-681. Image kindly provided by Dr. Chih-Hsin Tang.
Research Article|
April 01 2016
EEF1D modulates proliferation and epithelial–mesenchymal transition in oral squamous cell carcinoma
Isadora L. Flores;
Isadora L. Flores
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Rebeca Kawahara;
Rebeca Kawahara
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Márcia C.C. Miguel;
Márcia C.C. Miguel
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
‡Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
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Daniela C. Granato;
Daniela C. Granato
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Romênia R. Domingues;
Romênia R. Domingues
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Carolina C.S. Macedo;
Carolina C.S. Macedo
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Carolina M. Carnielli;
Carolina M. Carnielli
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Sami Yokoo;
Sami Yokoo
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Priscila C. Rodrigues;
Priscila C. Rodrigues
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Bárbara V.B. Monteiro;
Bárbara V.B. Monteiro
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
‡Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
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Carine E. Oliveira;
Carine E. Oliveira
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Cristiane R. Salmon;
Cristiane R. Salmon
§Departamento de Prótese e Periodontia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Francisco H. Nociti, Jr;
Francisco H. Nociti, Jr
§Departamento de Prótese e Periodontia, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Márcio A. Lopes;
Márcio A. Lopes
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Alan Santos-Silva;
Alan Santos-Silva
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
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Flavia V. Winck;
Flavia V. Winck
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
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Ricardo D. Coletta;
†Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, UNICAMP, Piracicaba, SP, Brazil
Correspondence: Professor Ricardo Coletta (email [email protected]) or Professor Adriana Paes Leme (email [email protected]).
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Adriana F. Paes Leme
*Laboratório de Espectrometria de Massas, Laboratório Nacional de Biociências, LNBio, CNPEM, Campinas, SP, Brazil
Correspondence: Professor Ricardo Coletta (email [email protected]) or Professor Adriana Paes Leme (email [email protected]).
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Publisher: Portland Press Ltd
Received:
September 15 2015
Revision Received:
January 21 2016
Accepted:
January 28 2016
Accepted Manuscript online:
January 28 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 Authors; published by Portland Press Limited
2016
Clin Sci (Lond) (2016) 130 (10): 785–799.
Article history
Received:
September 15 2015
Revision Received:
January 21 2016
Accepted:
January 28 2016
Accepted Manuscript online:
January 28 2016
Citation
Isadora L. Flores, Rebeca Kawahara, Márcia C.C. Miguel, Daniela C. Granato, Romênia R. Domingues, Carolina C.S. Macedo, Carolina M. Carnielli, Sami Yokoo, Priscila C. Rodrigues, Bárbara V.B. Monteiro, Carine E. Oliveira, Cristiane R. Salmon, Francisco H. Nociti, Márcio A. Lopes, Alan Santos-Silva, Flavia V. Winck, Ricardo D. Coletta, Adriana F. Paes Leme; EEF1D modulates proliferation and epithelial–mesenchymal transition in oral squamous cell carcinoma. Clin Sci (Lond) 1 May 2016; 130 (10): 785–799. doi: https://doi.org/10.1042/CS20150646
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