Normal skeletal muscle metabolism is essential for whole body metabolic homoeostasis and disruptions in muscle metabolism are associated with a number of chronic diseases. Transcriptional control of metabolic enzyme expression is a major regulatory mechanism for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation as epigenetic control points. The emerging cross-talk between metabolism and epigenetics in the context of health and disease will also be examined. The concept of inheritance of skeletal muscle metabolic phenotypes will be discussed, in addition to emerging epigenetic therapies that could be used to alter muscle metabolism in chronic disease states.
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Review Article| May 23 2016
Epigenetic regulation of skeletal muscle metabolism
Kirsten F. Howlett ;
Sean L. McGee
†Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria 3217, Australia
Correspondence: Sean L. McGee (email email@example.com).
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Kirsten F. Howlett, Sean L. McGee; Epigenetic regulation of skeletal muscle metabolism. Clin Sci (Lond) 1 July 2016; 130 (13): 1051–1063. doi: https://doi.org/10.1042/CS20160115
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