Protein phosphorylation is a highly-regulated and reversible process that is precisely controlled by the actions of protein kinases and protein phosphatases. Factors that tip the balance of protein phosphorylation lead to changes in a wide range of cellular responses, including cell proliferation, differentiation and survival. The protein kinase C (PKC) family of serine/threonine kinases sits at nodal points in many signal transduction pathways; PKC enzymes have been the focus of considerable attention since they contribute to both normal physiological responses as well as maladaptive pathological responses that drive a wide range of clinical disorders. This review provides a background on the mechanisms that regulate individual PKC isoenzymes followed by a discussion of recent insights into their role in the pathogenesis of diseases such as cancer. We then provide an overview on the role of individual PKC isoenzymes in the regulation of cardiac contractility and pathophysiological growth responses, with a focus on the PKC-dependent mechanisms that regulate pump function and/or contribute to the pathogenesis of heart failure.
Skip Nav Destination
Article navigation
September 2016
-
Cover Image
Cover Image
Corin protein expression in human renal proximal convoluted tubules as shown by brown staining in immunohistochemistry. See pp. 1655-1664 for further details. Image kindly provided by Qingyu Wu.
Review Article|
July 18 2016
Protein kinase C mechanisms that contribute to cardiac remodelling
Alexandra C. Newton;
*Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, U.S.A.
Correspondence: Susan F. Steinberg (email [email protected]) or Alexandra C. Newton (email [email protected]).
Search for other works by this author on:
Corina E. Antal;
Corina E. Antal
*Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, U.S.A.
†Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, U.S.A.
Search for other works by this author on:
Susan F. Steinberg
‡Department of Pharmacology, Columbia University, New York, NY 10032, U.S.A.
Correspondence: Susan F. Steinberg (email [email protected]) or Alexandra C. Newton (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 14 2016
Revision Received:
May 16 2016
Accepted:
May 18 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (17): 1499–1510.
Article history
Received:
January 14 2016
Revision Received:
May 16 2016
Accepted:
May 18 2016
Citation
Alexandra C. Newton, Corina E. Antal, Susan F. Steinberg; Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) 1 September 2016; 130 (17): 1499–1510. doi: https://doi.org/10.1042/CS20160036
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |