Protein phosphorylation is a highly-regulated and reversible process that is precisely controlled by the actions of protein kinases and protein phosphatases. Factors that tip the balance of protein phosphorylation lead to changes in a wide range of cellular responses, including cell proliferation, differentiation and survival. The protein kinase C (PKC) family of serine/threonine kinases sits at nodal points in many signal transduction pathways; PKC enzymes have been the focus of considerable attention since they contribute to both normal physiological responses as well as maladaptive pathological responses that drive a wide range of clinical disorders. This review provides a background on the mechanisms that regulate individual PKC isoenzymes followed by a discussion of recent insights into their role in the pathogenesis of diseases such as cancer. We then provide an overview on the role of individual PKC isoenzymes in the regulation of cardiac contractility and pathophysiological growth responses, with a focus on the PKC-dependent mechanisms that regulate pump function and/or contribute to the pathogenesis of heart failure.
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September 2016
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Corin protein expression in human renal proximal convoluted tubules as shown by brown staining in immunohistochemistry. See pp. 1655-1664 for further details. Image kindly provided by Qingyu Wu.Close Modal
Review Article|
July 18 2016
Protein kinase C mechanisms that contribute to cardiac remodelling
Alexandra C. Newton;
*Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, U.S.A.
Correspondence: Susan F. Steinberg (email sfs1@columbia.edu) or Alexandra C. Newton (email anewton@ucsd.edu).
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Corina E. Antal;
Corina E. Antal
*Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, U.S.A.
†Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, U.S.A.
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Susan F. Steinberg
‡Department of Pharmacology, Columbia University, New York, NY 10032, U.S.A.
Correspondence: Susan F. Steinberg (email sfs1@columbia.edu) or Alexandra C. Newton (email anewton@ucsd.edu).
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Clin Sci (Lond) (2016) 130 (17): 1499–1510.
Article history
Received:
January 14 2016
Revision Received:
May 16 2016
Accepted:
May 18 2016
Citation
Alexandra C. Newton, Corina E. Antal, Susan F. Steinberg; Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) 1 September 2016; 130 (17): 1499–1510. doi: https://doi.org/10.1042/CS20160036
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