The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity-mediated inflammation in neurovascular changes in diabetes.
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Review Article| September 15 2016
Cerebrovascular complications of diabetes: focus on cognitive dysfunction
*Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, U.S.A.
‡Charlie Norwood Veterans Administration Medical Center, Augusta, GA 30912, U.S.A.
Correspondence: Adviye Ergul (email email@example.com).
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Publisher: Portland Press Ltd
Accepted: July 11 2015
Received: May 27 2016
Revision Received: July 05 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
Trevor Hardigan, Rebecca Ward, Adviye Ergul; Cerebrovascular complications of diabetes: focus on cognitive dysfunction. Clin Sci (Lond) 1 October 2016; 130 (20): 1807–1822. doi: https://doi.org/10.1042/CS20160397
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