The discovery of endothelial progenitor cells (EPCs), a group of cells that play important roles in angiogenesis and the maintenance of vascular endothelial integrity, has led to considerable improvements in our understanding of the circulatory system and the regulatory mechanisms of vascular homoeostasis. Despite lingering disputes over where EPCs actually originate and how they facilitate angiogenesis, extensive research in the past decade has brought about significant advancements in this field of research, establishing EPCs as an essential element in the pathogenesis of various diseases. EPC and hypertensive disorders, especially essential hypertension (EH, also known as primary hypertension), represent one of the most appealing branches in this area of research. Chronic hypertension remains a major threat to public health, and the exact pathologic mechanisms of EH have never been fully elucidated. Is there a relationship between EPC and hypertension? If so, what is the nature of such relationship–is it mediated by blood pressure alterations, or other factors that lie in between? How can our current knowledge about EPCs be utilized to advance the prevention and clinical management of hypertension? In this review, we set out to answer these questions by summarizing the current concepts about EPC pathophysiology in the context of hypertension, while attempting to point out directions for future research on this subject.
Skip Nav Destination
Article navigation
November 2016
-
Cover Image
Cover Image
The effect on lung function and respiratory symptoms of reducing of consumption of conventional cigarettes by switching to electronic cigarettes is investigated by the Cibella et al. in their Clinical Science research article on pages 1929-1937 (volume 130, issue 21).
Review Article|
October 11 2016
Endothelial progenitor cells and hypertension: current concepts and future implications
Shengyuan Luo;
Shengyuan Luo
1
*Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Search for other works by this author on:
Wenhao Xia;
Wenhao Xia
1
*Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Search for other works by this author on:
Cong Chen;
Cong Chen
1
†Department of Cardiology, Maoming People's Hospital, Maoming, Guangdong 525000, China
Search for other works by this author on:
Eric A. Robinson;
Eric A. Robinson
‡Department of Internal Medicine, University of Arizona, Tucson, Arizona 85724, U.S.A.
Search for other works by this author on:
Jun Tao
*Department of Hypertension and Vascular Disease, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China
Correspondence: Jun Tao (email [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 01 2016
Revision Received:
September 07 2016
Accepted:
September 09 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (22): 2029–2042.
Article history
Received:
August 01 2016
Revision Received:
September 07 2016
Accepted:
September 09 2016
Citation
Shengyuan Luo, Wenhao Xia, Cong Chen, Eric A. Robinson, Jun Tao; Endothelial progenitor cells and hypertension: current concepts and future implications. Clin Sci (Lond) 1 November 2016; 130 (22): 2029–2042. doi: https://doi.org/10.1042/CS20160587
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |