Visceral adipose tissue is a primary site of chronic inflammation in obesity and may contribute to systemic inflammation and development of atherosclerotic vascular disease. Few studies identify molecular mechanisms and secretory pathways which mediate this process. In this edition of Clinical Science, Kwok et al. utilize a transgenic mouse in which dominant-negative c-Jun NH2 terminal kinase (dnJNK) expression is restricted to adipose tissue to implicate JNK-driven expression of adipocyte fatty acid binding protein (A-FABP) in visceral adipose tissue as a key secretory pathway to exacerbate development of atherosclerosis in ApoE-/- mice. They further demonstrate that ApoE-/- mice transplanted with visceral adipose tissue in which JNK has been inactivated display less systemic inflammation and develop significantly less atherosclerosis compared with control mice. Together, the findings of the present study reinforce our understanding of visceral adipose tissue as a secretory organ and the importance of the JNK/A-FABP pathway in mediating adipose vascular cross-talk and exacerbation of atherosclerosis.
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November 2016
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The effect on lung function and respiratory symptoms of reducing of consumption of conventional cigarettes by switching to electronic cigarettes is investigated by the Cibella et al. in their Clinical Science research article on pages 1929-1937 (volume 130, issue 21).
Commentary|
October 11 2016
Adipose inflammation at the heart of vascular disease
Michael V. Autieri
*Department of Physiology, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, U.S.A.
Correspondence: Dr Michael Autieri (email [email protected]).
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Publisher: Portland Press Ltd
Received:
August 10 2016
Revision Received:
September 07 2016
Accepted:
September 09 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (22): 2101–2104.
Article history
Received:
August 10 2016
Revision Received:
September 07 2016
Accepted:
September 09 2016
Connected Content
A commentary has been published:
Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice
Citation
Michael V. Autieri; Adipose inflammation at the heart of vascular disease. Clin Sci (Lond) 1 November 2016; 130 (22): 2101–2104. doi: https://doi.org/10.1042/CS20160628
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