Breast cancer (BC) survival rates have improved during the past two decades and as a result older BC survivors are at increased risk of developing heart failure (HF). Although the HF phenotype common to BC survivors has received little attention, BC survivors have a number of risk factors associated with HF and preserved ejection fraction (HFPEF) including older age, hypertension, obesity, metabolic syndrome and sedentary lifestyle. Moreover, not unlike HFPEF, BC survivors with preserved left ventricular ejection fraction (BCPEF) have reduced exercise tolerance measured objectively as decreased peak oxygen uptake (peak VO2). This review summarizes the literature regarding the mechanisms of exercise intolerance and the role of exercise training to improve peak VO2 in BCPEF.
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December 2016
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IL-13 induced actin cytoskeleton rearrangement in human podocytes. Magnification, x60, scale bar, 20μm. For more information please see pp. 2317-2327. Image provided by Chan Chang Yien.
Review Article|
November 04 2016
Pathophysiology of exercise intolerance in breast cancer survivors with preserved left ventricular ejection fraction
Mark J. Haykowsky;
*College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, USA
†Sport Cardiology, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia
Correspondence: Prof. Mark J. Haykowsky (email [email protected])
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Rhys Beaudry;
Rhys Beaudry
*College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, USA
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R. Matthew Brothers;
R. Matthew Brothers
*College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, USA
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Michael D. Nelson;
Michael D. Nelson
*College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76019, USA
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Satyam Sarma;
Satyam Sarma
‡Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX 75231, USA
§Department of Internal Medicine, University of Texas Southwestern Medical Branch, Dallas, TX 75390, USA
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Andre La Gerche
Andre La Gerche
†Sport Cardiology, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia
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Publisher: Portland Press Ltd
Received:
June 29 2016
Revision Received:
September 08 2016
Accepted:
September 20 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (24): 2239–2244.
Article history
Received:
June 29 2016
Revision Received:
September 08 2016
Accepted:
September 20 2016
Citation
Mark J. Haykowsky, Rhys Beaudry, R. Matthew Brothers, Michael D. Nelson, Satyam Sarma, Andre La Gerche; Pathophysiology of exercise intolerance in breast cancer survivors with preserved left ventricular ejection fraction. Clin Sci (Lond) 1 December 2016; 130 (24): 2239–2244. doi: https://doi.org/10.1042/CS20160479
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