Chemotherapeutic response is critical for the successful treatment and good prognosis in cancer patients. In this study, we analysed the gene expression profiles of preoperative samples from oestrogen receptor (ER)-negative breast cancer patients with different responses to taxane-anthracycline-based (TA-based) chemotherapy, and identified a group of genes that was predictive. Pregnancy specific beta-1-glycoprotein 1 (PSG1) played a central role within signalling pathways of these genes. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-β (TGF-β)-related pathway in ER-negative breast cancer cells. Drug screening then identified dicumarol (DCM) to target the PSG1 and inhibit chemoresistance to TA-based chemotherapy in vitro, in vivo, and in clinical samples. Taken together, this study highlights PSG1 as an important mediator of chemoresistance, whose effect could be diminished by DCM.
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IL-13 induced actin cytoskeleton rearrangement in human podocytes. Magnification, x60, scale bar, 20μm. For more information please see pp. 2317-2327. Image provided by Chan Chang Yien.
Research Article|
November 04 2016
Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol
Dong-xu He;
Dong-xu He
1
*National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China
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Feng Gu;
Feng Gu
1
†Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
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Jian Wu;
Jian Wu
1
‡State Key Laboratory of Bioelectronics, Southeast University Sipailou 2#, Nanjing 210096, China
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Xiao-Ting Gu;
Xiao-Ting Gu
§Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
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Chun-Xiao Lu;
Chun-Xiao Lu
§Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
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Ai-qin Mao;
Ai-qin Mao
§Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
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Guang-yuan Zhang;
Guang-yuan Zhang
*National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China
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Zhong-yang Ding;
Zhong-yang Ding
*National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China
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Jin-ke Wang;
Jin-ke Wang
‡State Key Laboratory of Bioelectronics, Southeast University Sipailou 2#, Nanjing 210096, China
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Jun-jun Hao;
║State Key Lab of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
Correspondence: Xin Ma (email [email protected]), Li Fu (email [email protected]) or Jun-jun Hao (email [email protected]).
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Li Fu;
†Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
Correspondence: Xin Ma (email [email protected]), Li Fu (email [email protected]) or Jun-jun Hao (email [email protected]).
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Xin Ma
§Department of Cellular and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
Correspondence: Xin Ma (email [email protected]), Li Fu (email [email protected]) or Jun-jun Hao (email [email protected]).
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Publisher: Portland Press Ltd
Received:
July 14 2016
Revision Received:
September 07 2016
Accepted:
September 20 2016
Accepted Manuscript online:
September 21 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (24): 2267–2276.
Article history
Received:
July 14 2016
Revision Received:
September 07 2016
Accepted:
September 20 2016
Accepted Manuscript online:
September 21 2016
Citation
Dong-xu He, Feng Gu, Jian Wu, Xiao-Ting Gu, Chun-Xiao Lu, Ai-qin Mao, Guang-yuan Zhang, Zhong-yang Ding, Jin-ke Wang, Jun-jun Hao, Li Fu, Xin Ma; Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol. Clin Sci (Lond) 1 December 2016; 130 (24): 2267–2276. doi: https://doi.org/10.1042/CS20160536
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