Preeclampsia (PE) is a hypertensive pregnancy disorder complicating up to 1–5% of pregnancies, and a major cause of maternal and fetal morbidity and mortality. In recent years, observational studies have consistently shown that PE carries an increased risk for the mother to develop cardiovascular and renal disease later in life. Women with a history of PE experience a 2-fold increased risk of long-term cardiovascular disease (CVD) and an approximate 5–12-fold increased risk of end-stage renal disease (ESRD). Recognition of PE as a risk factor for renal disease and CVD allows identification of a young population of women at high risk of developing of cardiovascular and renal disease. For this reason, current guidelines recommend cardiovascular screening and treatment for formerly preeclamptic women. However, these recommendations are based on low levels of evidence due to a lack of studies on screening and prevention in formerly preeclamptic women. This review lists the incidence of premature CVD and ESRD observed after PE and outlines observed abnormalities that might contribute to the increased CVD risk with a focus on kidney-related disturbances. We discuss gaps in current knowledge to guide optimal screening and prevention strategies. We emphasize the need for research on mechanisms of late disease manifestations, and on effective screening and therapeutic strategies aimed at reducing the late disease burden in formerly preeclamptic women.
Skip Nav Destination
Article navigation
February 2016
-
Cover Image
Cover Image
Image modified from a figure representing the 5 mechanisms of annexin A1 externalization through non-classic secretory pathways, discussed by Boudhraa et al in issue 130(4) of Clinical Science. For further details please see pp. 205–220. Image kindly provided by Z. Boudhraa, B. Bouchon, C. Viallard, M. D'Incan and F. Degoul.
Review Article|
January 14 2016
Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention
Nina D. Paauw;
*Department of Obstetrics, Wilhelmina Children's Hospital Birth Center, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Correspondence: Nina D. Paauw (email [email protected]).
Search for other works by this author on:
Kim Luijken;
Kim Luijken
*Department of Obstetrics, Wilhelmina Children's Hospital Birth Center, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Search for other works by this author on:
Arie Franx;
Arie Franx
*Department of Obstetrics, Wilhelmina Children's Hospital Birth Center, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Search for other works by this author on:
Marianne C. Verhaar;
Marianne C. Verhaar
†Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Search for other works by this author on:
A. Titia Lely
A. Titia Lely
*Department of Obstetrics, Wilhelmina Children's Hospital Birth Center, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 19 2015
Revision Received:
November 13 2015
Accepted:
November 25 2015
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 Authors; published by Portland Press Limited
2016
Clin Sci (Lond) (2016) 130 (4): 239–246.
Article history
Received:
August 19 2015
Revision Received:
November 13 2015
Accepted:
November 25 2015
Citation
Nina D. Paauw, Kim Luijken, Arie Franx, Marianne C. Verhaar, A. Titia Lely; Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention. Clin Sci (Lond) 1 February 2016; 130 (4): 239–246. doi: https://doi.org/10.1042/CS20150567
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |