Understanding the negative health consequences of a physical inactivity has been the topic of much investigation as an alarming number of adults have adopted a sedentary lifestyle. With the rise in sedentarism the field of inactivity physiology has emerged. The goal of inactivity physiology is to identify the impact in inactivity on health and develop strategies that effectively minimize the risk of a sedentary lifestyle. Arising from this field is the finding that excessive sitting is linked to increased cardiovascular and metabolic disease and all-cause mortality. Most importantly, these relationships exist even in individuals that are physically active. Clearly, excessive sitting is an occupational hazard with significant health consequences. Through a series of investigations, including research published this issue of Clinical Science, Padilla and colleagues have identified that prolonged sitting evokes vascular dysfunction and that this dysfunction is caused by reduced shear stress. This commentary highlights this series of investigations and culminates with an overview of how prior exercise and standing are effective strategies to circumvent vascular dysfunction that is caused by excessive sitting.
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Cover ImageThe accompanying caption is: Image demonstrates a 3D reconstruction of the neurovascular unit in a hippocampal artery in the mouse brain. For further details, see article by Nizari et al in this issue, pages 1207-1214. Image kindly provided by Cheryl Hawkes.Close Modal
Commentary| May 10 2017
Something is definitely better than nothing: simple strategies to prevent vascular dysfunction
Joel D. Trinity
1Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah, U.S.A.
2Geriatric Research, Education, and Clinical Center, George E. Whalen VA Medical Center, Salt Lake City, Utah, U.S.A.
3Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, U.S.A.
Correspondence: Joel D. Trinity (email@example.com)
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Clin Sci (Lond) (2017) 131 (11): 1055–1058.
March 14 2017
April 10 2017
April 12 2017
This is a commentary on: Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction
Joel D. Trinity; Something is definitely better than nothing: simple strategies to prevent vascular dysfunction. Clin Sci (Lond) 1 June 2017; 131 (11): 1055–1058. doi: https://doi.org/10.1042/CS20170130
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