This commentary highlights the research presented by Zhu et al. . In this issue of the Clinical Science, the authors evaluated the protective effect of Alda-1 (a novel class of small molecule aldehyde dehydrogenase (ALDH2) activators) in the intestinal ischemia reperfusion (IR) injury. Remarkably, enhancing the ADLH2 activity by the use of Alda-1 can ameliorate several deleterious effects related to aldehydes, and may provide a better protection against an injury preestablished by IR. Together, an innovative metabolic strategy for treating patients with IR injury could be the use of ALDH modulators in a near future.
Keywords:Alda-1, ALDH, biobanking, ischemia reperfusion
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society