Inhibitors of phosphodiesterase 5 (PDE5) – sildenafil citrate (Viagra; Pfizer) and vardenafil hydrochloride (Levitra; Bayer/GlaxoSmithKline) – approved for the treatment of erectile dysfunction and pulmonary arterial hypertension also rescue the loss of cystic fibrosis (CF) chloride channel function and the mislocalization of F508del-CFTR in affected tissues in CF. Can PDE5 inhibitors provide a therapeutic strategy which combines ability to correct the basic ion transport defect and to control de-regulated lung inflammation in CF?
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Commentary| May 22 2017
Classical activation of macrophages and vardenafil
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Richmond Muimo; Classical activation of macrophages and vardenafil. Clin Sci (Lond) 1 June 2017; 131 (11): 1141–1145. doi: https://doi.org/10.1042/CS20170137
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