Glutamate-mediated excitotoxicity is the major neuropathological process contributing to numerous neurological diseases. Recently, emerging evidence indicates that microRNAs (miRNAs) play essential roles in the pathophysiology of a wide range of neurological diseases. Notably, there have been significant developments in understanding the biogenesis of miRNAs, their regulatory mechanisms, and their potential as effective biomarkers and therapies. In the present review, we summarize the recent literature that highlights the versatile roles played by miRNAs in glutamate receptor (GluR)-dependent neurological diseases. Based on the reported studies to date, modulation of miRNAs could emerge as a promising therapeutic target for a variety of neurological diseases that were discussed in this review.
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July 2017
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This issue of Clinical Science showcases review articles covering kidney disease, the respiratory system, neurology and oxidative stress.
Review Article|
June 30 2017
MicroRNA in glutamate receptor-dependent neurological diseases
Walid A. Alsharafi;
Walid A. Alsharafi
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
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Zhaohui Luo;
Zhaohui Luo
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
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Xiaoyan Long;
Xiaoyan Long
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
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Yuanyuan Xie;
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Correspondence: Bo Xiao ([email protected]) or Yuanyuan Xie ([email protected])
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Bo Xiao
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Correspondence: Bo Xiao ([email protected]) or Yuanyuan Xie ([email protected])
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Publisher: Portland Press Ltd
Received:
April 05 2017
Revision Received:
May 05 2017
Accepted:
May 15 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (14): 1591–1604.
Article history
Received:
April 05 2017
Revision Received:
May 05 2017
Accepted:
May 15 2017
Citation
Walid A. Alsharafi, Zhaohui Luo, Xiaoyan Long, Yuanyuan Xie, Bo Xiao; MicroRNA in glutamate receptor-dependent neurological diseases. Clin Sci (Lond) 15 July 2017; 131 (14): 1591–1604. doi: https://doi.org/10.1042/CS20170964
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