Bronchopulmonary dysplasia (BPD) is a chronic illness that usually originates in preterm newborns. Generally, BPD is a consequence of respiratory distress syndrome (RDS) which, in turn, comes from the early arrest of lung development and the lack of pulmonary surfactant. The need of oxygen therapy to overcome premature newborns’ compromised respiratory function generates an increasing amount of reactive oxygen species (ROS), the onset of sustained oxidative stress (OS) status, and inflammation in the pulmonary alveoli deputies to respiratory exchanges. BPD is a severe and potentially life-threatening disorder that in the most serious cases, can open the way to neurodevelopmental delay. More importantly, there is no adequate intervention to hamper or treat BPD. This perspective article seeks to review the most recent and relevant literature describing the very early stages of BPD and hyperoxic lung injuries focussing on nuclear factor erythroid derived 2 (Nrf2)/heme oxygenase-1 (HO-1) axis. Indeed, Nrf2/HO1 activation in response to OS induced lung injury in preterm concurs to the induction of certain number of antioxidant, anti-inflammatory, and detoxification pathways that seem to be more powerful than the activation of one single antioxidant gene. These elicited protective effects are able to counteract/mitigate all multifaceted aspects of the disease and may support novel approaches for the management of BPD.
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July 2017
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This issue of Clinical Science showcases review articles covering kidney disease, the respiratory system, neurology and oxidative stress.
Review Article|
June 30 2017
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries
Emanuele Amata;
Emanuele Amata
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Valeria Pittalà;
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
Correspondence: Valeria Pittalà ([email protected]) or Seyed Mohammad Nabavi ([email protected])
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Agostino Marrazzo;
Agostino Marrazzo
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Carmela Parenti;
Carmela Parenti
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Orazio Prezzavento;
Orazio Prezzavento
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Emanuela Arena;
Emanuela Arena
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Seyed Mohammad Nabavi;
2Department Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395 5487, Tehran, Iran
Correspondence: Valeria Pittalà ([email protected]) or Seyed Mohammad Nabavi ([email protected])
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Loredana Salerno
Loredana Salerno
1Department of Drug Sciences, University of Catania, viale A. Doria 6, 95125 Catania, Italy
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Publisher: Portland Press Ltd
Received:
February 16 2017
Revision Received:
May 11 2017
Accepted:
May 16 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (14): 1701–1712.
Article history
Received:
February 16 2017
Revision Received:
May 11 2017
Accepted:
May 16 2017
Citation
Emanuele Amata, Valeria Pittalà, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Emanuela Arena, Seyed Mohammad Nabavi, Loredana Salerno; Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries. Clin Sci (Lond) 15 July 2017; 131 (14): 1701–1712. doi: https://doi.org/10.1042/CS20170157
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