Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical structure of curcumin as diferuloylmethane was reported by Milobedzka et al. [(1910) 43., 2163-2170]. Since then, this polyphenol has been shown to exhibit antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antifungal activities. The current review primarily focuses on the anticancer potential of curcumin through the modulation of multiple cell signaling pathways. Curcumin modulates diverse transcription factors, inflammatory cytokines, enzymes, kinases, growth factors, receptors, and various other proteins with an affinity ranging from the pM to the mM range. Furthermore, curcumin effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review is to discuss the molecular basis for the anticancer activities of curcumin based on preclinical and clinical findings.
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August 2017
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Human vascular smooth muscle cell derived from a skin precursor. Subjects with type-2 diabetes have fewer skin-derived precursors in their skin. Vascular smooth muscle cells derived from skin-derived precursors from subjects with type-2 diabetes carry persistent signatures of disease even weeks after being removed from the patient. Thus, skin-derived precursors may be a promising platform to study type-2 diabetes associated vascular disease in a dish. In Clinical Science volume 131, issue 15, Steinbach et al. describe new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin (see pages 1801-1814).
Review Article|
July 05 2017
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
Ajaikumar B. Kunnumakkara;
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India
Correspondence: Bharat B. Aggarwal ([email protected]) or Ajaikumar B. Kunnumakkara ([email protected])
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Devivasha Bordoloi;
Devivasha Bordoloi
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India
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Choudhary Harsha;
Choudhary Harsha
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India
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Kishore Banik;
Kishore Banik
1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India
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Subash C. Gupta;
Subash C. Gupta
2Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India
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Bharat B. Aggarwal
3Inflammation Research Center, San Diego, California, U.S.A.
Correspondence: Bharat B. Aggarwal ([email protected]) or Ajaikumar B. Kunnumakkara ([email protected])
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Publisher: Portland Press Ltd
Received:
December 03 2016
Revision Received:
April 05 2017
Accepted:
April 21 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (15): 1781–1799.
Article history
Received:
December 03 2016
Revision Received:
April 05 2017
Accepted:
April 21 2017
Citation
Ajaikumar B. Kunnumakkara, Devivasha Bordoloi, Choudhary Harsha, Kishore Banik, Subash C. Gupta, Bharat B. Aggarwal; Curcumin mediates anticancer effects by modulating multiple cell signaling pathways. Clin Sci (Lond) 1 August 2017; 131 (15): 1781–1799. doi: https://doi.org/10.1042/CS20160935
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