It is widely recognized that oxygen-derived free radicals have a central role in both normal physiological function and the pathophysiology of disease [1,2]. Under normal physiological conditions, reactive oxygen species are formed via the metabolism of oxygen molecules leading to the production of reactive oxygen species that have important mechanistic roles in signalling across a wide array of cell types and tissues. Numerous cellular enzymes are key to the production of reactive oxygen species including the NADPH oxidase enzyme (NOX) that was first described in neutrophils and recognized for its role in free radical-mediated defence against pathogens [13]. The control of reactive oxygen species production is achieved through a balance of enzymes that produce the free radicals and those that scavenge and metabolize them. As is the case for all physiological systems, failure of this homoeostatic balance leads to impaired tissue dysfunction and disease...
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January 2017
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Masson staining of rat liver specimens. Please see pp. 159-168 for more information. Image provided by Xujiong Li.
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December 23 2016
Oxidative stress–call for papers
Michael J. Ryan
*Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216-4505, U.S.A.
Correspondence: Professor Michael J. Ryan (email [email protected])
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Publisher: Portland Press Ltd
Received:
November 06 2016
Revision Received:
November 19 2016
Accepted:
November 22 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2017) 131 (2): 139–140.
Article history
Received:
November 06 2016
Revision Received:
November 19 2016
Accepted:
November 22 2016
Citation
Michael J. Ryan; Oxidative stress–call for papers. Clin Sci (Lond) 1 January 2017; 131 (2): 139–140. doi: https://doi.org/10.1042/CS20160619
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