For many years, oxidative stress arising from the ubiquitous production of reactive oxygen species (ROS) has been implicated in the pathogenesis of various eye diseases. While emerging research has provided some evidence of the important physiological role of ROS in normal cell function, disease may arise where the concentration of ROS exceeds and overwhelms the body’s natural defence against them. Additionally, ROS may induce genomic aberrations which affect cellular homoeostasis and may result in disease. This literature review examines the current evidence for the role of oxidative stress in important ocular diseases with a view to identifying potential therapeutic targets for future study. The need is particularly pressing in developing treatments for conditions which remain notoriously difficult to treat, including glaucoma, diabetic retinopathy and age-related macular degeneration.
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December 2017
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Wheat germ agglutinin staining of the adult mouse heart transverse section. In their study, Diniz et al., shows microRNA-22 regulates dyslipidemia and energy expenditure. For more information please see pages 2885-2900. Image kindly provided by Da-Zhi Wang
Review Article|
December 04 2017
Oxidative stress and reactive oxygen species: a review of their role in ocular disease
Lawson Ung;
Lawson Ung
1Save Sight Institute, University of Sydney, Sydney, NSW 2000, Australia
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Ushasree Pattamatta;
Ushasree Pattamatta
2Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia
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Nicole Carnt;
Nicole Carnt
2Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia
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Jennifer L. Wilkinson-Berka;
Jennifer L. Wilkinson-Berka
3Department of Diabetes, The Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia
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Gerald Liew;
Gerald Liew
2Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia
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Andrew J.R. White
1Save Sight Institute, University of Sydney, Sydney, NSW 2000, Australia
2Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia
Correspondence: Andrew White ([email protected])
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Publisher: Portland Press Ltd
Received:
July 26 2017
Revision Received:
October 26 2017
Accepted:
November 06 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (24): 2865–2883.
Article history
Received:
July 26 2017
Revision Received:
October 26 2017
Accepted:
November 06 2017
Citation
Lawson Ung, Ushasree Pattamatta, Nicole Carnt, Jennifer L. Wilkinson-Berka, Gerald Liew, Andrew J.R. White; Oxidative stress and reactive oxygen species: a review of their role in ocular disease. Clin Sci (Lond) 15 December 2017; 131 (24): 2865–2883. doi: https://doi.org/10.1042/CS20171246
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