Arterial stiffness is an independent indicator of cardiovascular risk. Autoantibodies (AAs) against angiotensin AT1 receptor (AT1-AAs) and α1-adrenergic receptor (α1-AAs) are important in the pathogenesis of hypertension. We identified the types of AT1-AAs and α1-AAs in normotensive subjects, with the aim of determining whether these antibodies predict aortic stiffness progression. Carotid–femoral pulse wave velocity (cf-PWV) was used to measure aortic stiffness. Overall, 816 subjects (71% of those invited) underwent a medical examination and evaluation of aortic stiffness. The types of AT1-AAs and α1-AAs were measured at baseline. Meanwhile, plasma renin, angiotensin II (Ang II), and norepinephrine (NE) concentrations were measured at baseline and follow-up. Baseline mean cf-PWV was 9.90 ± 0.84 m/s and follow-up was 10.51 ± 1.12 m/s. The annualized ΔPWV was 0.12 ± 0.08 m/s/year. At the end of follow-up, 129 normotensive subjects developed hypertension and 144 subjects had PWV progression. After adjustment for covariates, AA type was independently associated with ΔPWV, annualized ΔPWV, and abnormal PWV. In our study, the risk of developing hypertension (RR =2.028, 95% CI: 1.227–3.351, P=0.006) and PWV progression (RR =2.910, 95% CI: 1.612–5.253, P<0.001) in AA-positive subjects was significantly higher than that in AA-negative subjects. Receiver operating characteristic (ROC) curve showed AA had an identify power to discriminate subjects with or without PWV and hypertension progression. We have shown for the first time that the types of A1-AAs and α1-AAs are independent predictors for aortic stiffness progression in normotensive subjects. Our data collectively support the utility of these AAs as potential markers of aortic stiffness.
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Research Article|
December 08 2017
Autoantibodies against AT1 and α1-adrenergic receptors predict arterial stiffness progression in normotensive subjects over a 5-year period
Gang Li;
Gang Li
*
1Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
2Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China
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Zhe Cao;
Zhe Cao
*
3Department of Cardiology, The Central Hospital of Wuhan, Wuhan, China
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Xiao-wei Wu;
Xiao-wei Wu
4Department of Thoracic Surgery, Tong Ji Hospital, Tong Ji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Hui-kun Wu;
Hui-kun Wu
*
5Department of Hepatology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China
6Hepatology Department, Institute of Hepatology, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China
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Yi Ma;
Yi Ma
1Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
2Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China
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Bin Wu;
Bin Wu
1Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
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Wei-qing Wang;
Wei-qing Wang
1Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
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Jian Cheng;
Jian Cheng
7Emergency Department, Wuhan General Hospital of Guangzhou Military Command, Wuhan, China
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Zi-hua Zhou;
Zi-hua Zhou
8Department of Cardiology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Yuan-chao Tu
1Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
2Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China
Correspondence: Yuan-chao Tu ([email protected])
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Publisher: Portland Press Ltd
Received:
August 25 2017
Revision Received:
October 24 2017
Accepted:
November 01 2017
Accepted Manuscript online:
November 02 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (24): 2947–2957.
Article history
Received:
August 25 2017
Revision Received:
October 24 2017
Accepted:
November 01 2017
Accepted Manuscript online:
November 02 2017
Connected Content
A commentary has been published:
Autoantibodies against angiotensin and adrenergic receptors: more than a biomarker?
Citation
Gang Li, Zhe Cao, Xiao-wei Wu, Hui-kun Wu, Yi Ma, Bin Wu, Wei-qing Wang, Jian Cheng, Zi-hua Zhou, Yuan-chao Tu; Autoantibodies against AT1 and α1-adrenergic receptors predict arterial stiffness progression in normotensive subjects over a 5-year period. Clin Sci (Lond) 15 December 2017; 131 (24): 2947–2957. doi: https://doi.org/10.1042/CS20171305
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