Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced stages that require renal replacement therapy. Although much progress has been made in prevention, detection and treatment, CKD remains a major public health problem. Its global prevalence is estimated at 5–10% and, primarily because of cardiovascular morbidity and mortality, the global burden of CKD-associated diseases is alarmingly high [1].

The scope of Clinical Science is to translate molecular bioscience and experimental research into medical insights. CKD is a prime example of a disease in need of a truly translational approach that unravels pathophysiological mechanisms to develop new diagnostic, preventative and therapeutic strategies for the benefit of patients at risk of...

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