Influenza A viruses (IAVs) cause respiratory illness of varying severity based on the virus strains, host predisposition and pre-existing immunity. Ultimately, outcome and recovery from infection rely on an effective immune response comprising both innate and adaptive components. The innate immune response provides the first line of defence and is crucial to the outcome of infection. Airway epithelial cells are the first cell type to encounter the virus in the lungs, providing antiviral and chemotactic molecules that shape the ensuing immune response by rapidly recruiting innate effector cells such as NK cells, monocytes and neutrophils. Each cell type has unique mechanisms to combat virus-infected cells and limit viral replication, however their actions may also lead to pathology. This review focuses how innate cells contribute to protection and pathology, and provides evidence for their involvement in immune pathology in IAV infections.
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February 2017
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Density-dependent scanning electron microscopy of calcifying vascular tissue (orange - calcification; green - collagen). Please see pp. 181-195 for more information. Image provided by Sergio Bertazzo.
Review Article|
January 20 2017
Contribution of innate immune cells to pathogenesis of severe influenza virus infection
Suzanne L. Cole;
Suzanne L. Cole
*MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, U.K.
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Ling-Pei Ho
*MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, U.K.
Correspondence: Professor Ling-Pei Ho (email [email protected])
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Publisher: Portland Press Ltd
Received:
September 28 2016
Revision Received:
November 19 2016
Accepted:
November 25 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (4): 269–283.
Article history
Received:
September 28 2016
Revision Received:
November 19 2016
Accepted:
November 25 2016
Citation
Suzanne L. Cole, Ling-Pei Ho; Contribution of innate immune cells to pathogenesis of severe influenza virus infection. Clin Sci (Lond) 1 February 2017; 131 (4): 269–283. doi: https://doi.org/10.1042/CS20160484
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