The pathogenesis of thoracic aortic aneurysm and dissection (TAAD) is complex and incompletely understood. The hallmarks of the disease process are aortic inflammatory cell infiltration and protease mediated elastic fiber disruption. In a study recently published in Clinical Science (2018) 132 (6), 655–668), Liu et al. explore the mechanism through which aortic vascular smooth cells and macrophages participate in TAAD using a mouse model. The authors propose that interleukin-3 (IL-3) released from aortic vascular smooth cells is central to the disease process. IL-3 stimulated matrix metalloproteinase 12 (MMP12) release from macrophages via mitogen activated protein kinase pathways. MMP12 is a protease known to be involved in both aortic aneurysm and dissection. IL-3 knockout mice had significantly reduced aortic wall MMP12, and reduced protease activity. This was associated with protection against TAAD.
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June 2018
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Double immunofluorescence staining for mindin (red) and CD68 (green) in atherosclerotic plaques of HFD-treated APOE-/- mice. In Issue 11 of Clinical Science, Zhu et al. discuss mindin deficiency as a novel mediator in protecting against foam cell formation and atherosclerosis, through direct interaction with LXR-β; for details, see pages 1199–1213.
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June 21 2018
Interleukin-3 is required for thoracic aneurysm and dissection in a mouse model
Clinton S. Robbins;
Clinton S. Robbins
1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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John S. Byrne
2Division of Vascular Surgery, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
Correspondence: John S. Byrne ([email protected])
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Publisher: Portland Press Ltd
Received:
May 04 2018
Revision Received:
May 16 2018
Accepted:
May 18 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (12): 1253–1256.
Article history
Received:
May 04 2018
Revision Received:
May 16 2018
Accepted:
May 18 2018
Connected Content
Citation
Clinton S. Robbins, John S. Byrne; Interleukin-3 is required for thoracic aneurysm and dissection in a mouse model. Clin Sci (Lond) 29 June 2018; 132 (12): 1253–1256. doi: https://doi.org/10.1042/CS20180185
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