An established body of knowledge and clinical practice has argued in favor of the use of glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the very well-known adverse effects associated with their treatment hampers continuation of therapy with glucocorticoids. Analyses of the molecular mechanisms underlying the actions of glucocorticoids have led to the discovery of several mediators that add complexity and diversity to the puzzling world of these hormones and anti-inflammatory drugs. Such mediators hold great promise as alternative pharmacologic tools to be used as anti-inflammatory drugs with the same properties as glucocorticoids, but avoiding their metabolic side effects. This review summarizes findings about the molecular targets and mediators of glucocorticoid function.
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July 2018
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The 3D structure of recombinant human deoxyribonuclease I. The N-terminal leucine shown in yellow at the top of the structure was selected for PEGylation of the protein. The amino acids shown in yellow towards the bottom of the protein are those interacting with globular actin, a potent inhibitor of human deoxyribonuclease I; for details, see pages 1439–1452.
Research Article|
July 31 2018
Defining the role of glucocorticoids in inflammation
Simona Ronchetti;
Simona Ronchetti
1Department of Medicine, Section of Pharmacology, University of Perugia, Piazza Severi 1, Perugia 06132, Italy
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Graziella Migliorati;
Graziella Migliorati
1Department of Medicine, Section of Pharmacology, University of Perugia, Piazza Severi 1, Perugia 06132, Italy
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Stefano Bruscoli;
Stefano Bruscoli
1Department of Medicine, Section of Pharmacology, University of Perugia, Piazza Severi 1, Perugia 06132, Italy
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Carlo Riccardi
1Department of Medicine, Section of Pharmacology, University of Perugia, Piazza Severi 1, Perugia 06132, Italy
Correspondence: Carlo Riccardi ([email protected])
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Publisher: Portland Press Ltd
Received:
March 28 2018
Revision Received:
June 14 2018
Accepted:
July 09 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (14): 1529–1543.
Article history
Received:
March 28 2018
Revision Received:
June 14 2018
Accepted:
July 09 2018
Citation
Simona Ronchetti, Graziella Migliorati, Stefano Bruscoli, Carlo Riccardi; Defining the role of glucocorticoids in inflammation. Clin Sci (Lond) 31 July 2018; 132 (14): 1529–1543. doi: https://doi.org/10.1042/CS20171505
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