Low-level BK polyomavirus (BKPyV) shedding is seen in at least 10% of seropositive immunocompetent adults. Moreover, BKPyV infection is highly prevalent amongst immunocompromised populations, yet little is known on its relationship with malignancy. We studied a female patient with BKPyV-associated and donor-derived de novo high-grade sarcomatoid urothelial carcinoma developed 8 years after kidney transplantation from a male donor. Through whole-genome sequencing, we discovered integration of genotype IV BKPyV genome into the non-coding RNA (ncRNA) intronic region of human chromosome 18. The two breakpoints in the virus genome were located at the non-coding control region (NCCR) and large T antigen (TAg) coding region, respectively. Nevertheless, the TAg was overexpressed. We, therefore, inferred that the BKPyV was clonally integrated into the human genome in the form of concatemers, facilitating the expression of the TAg. The patient presented with multiorgan metastases, which were reduced in size and number throughout the body after removal of the graft and cessation of immunosuppressants. The few remaining lesions located in the liver were identified, through biopsy to be necrotic tumor tissue with TAg detected; additionally, genomic sequencing of the liver mass found Y chromosome. In conclusion, we propose that integration of the BKPyV genome is closely related to oncogenesis in this patient; while oncogenesis occurred when host immunity was impaired, recovery of the patient’s native immunity effectively curbed viral replication and eliminated the metastatic lesions.
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August 2018
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A depiction of the mechanism of cellular autophagy showing the fusion of a lysosome with an autophagosome. The various molecules involved in the process can be seen alongside different microbes within the autophagosome. In this issue of Clinical Science, Li et al. (issue 15, pages 1645–1667) investigate the role of HMGB1-induced autophagy in liver fibrosis, and Andrade-Silva et al. (issue 16, pages 1725–1739) discuss the involvement of TLR2 and TLR4 in autophagy associated with cisplatin-induced acute kidney injury.
Research Article|
August 30 2018
Occurrence and regression of BK polyomavirus associated carcinoma: a clinical and next-generation sequencing study
Fangxiang Fu;
Fangxiang Fu
*
1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Wenfeng Deng;
Wenfeng Deng
*
2Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Siyuan Yu;
Siyuan Yu
3The Second Clinical Medical School, Southern Medical University, Guangzhou 510515, China
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Yanna Liu;
Yanna Liu
1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Lixin Yu;
Lixin Yu
2Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Rumin Liu;
Rumin Liu
2Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Jiping Lang;
Jiping Lang
1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Dianxiang Geng;
Dianxiang Geng
4Department of Information Analysis, Vazyme Biotech Co.,Ltd., Nanjing 210000, China
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Jian Geng;
Jian Geng
5Department of Pathology, Southern Medical University, Guangzhou 510515, China
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Jiangtao Li;
Jiangtao Li
1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Gang Huang;
Gang Huang
6Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
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Minhua Luo;
Minhua Luo
7State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Wuhan, China
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Fu Xiong;
Fu Xiong
8Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
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Chin-Lee Wu;
Chin-Lee Wu
9Departments of Pathology and Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, U.S.A.
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Yun Miao
2Organ Transplant Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Correspondence: Yun Miao ([email protected])
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Publisher: Portland Press Ltd
Received:
May 31 2018
Revision Received:
July 07 2018
Accepted:
July 17 2018
Accepted Manuscript online:
July 19 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (16): 1753–1763.
Article history
Received:
May 31 2018
Revision Received:
July 07 2018
Accepted:
July 17 2018
Accepted Manuscript online:
July 19 2018
Citation
Fangxiang Fu, Wenfeng Deng, Siyuan Yu, Yanna Liu, Lixin Yu, Rumin Liu, Jiping Lang, Dianxiang Geng, Jian Geng, Jiangtao Li, Gang Huang, Minhua Luo, Fu Xiong, Chin-Lee Wu, Yun Miao; Occurrence and regression of BK polyomavirus associated carcinoma: a clinical and next-generation sequencing study. Clin Sci (Lond) 31 August 2018; 132 (16): 1753–1763. doi: https://doi.org/10.1042/CS20180443
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