Systemic acid-base balance is tightly controlled within a narrow range of pH. Disturbances in systemic acid-base homeostasis are associated with diverse detrimental effects. The kidney is a key regulator of acid-base balance, capable of excreting HCO3− or H+, and chronic kidney disease invariably leads to acidosis. However, the regulatory pathways underlying the fine-tuned acid-base sensing and regulatory mechanisms are still incompletely understood. In the article published recently in Clinical Science (vol 132 (16) 1779-1796), Poulson and colleagues investigated the role of adenylyl cyclase 6 (AC6) in acid-base homeostasis. They uncovered a complex role of AC6, specifically affecting acid-base balance during HCO3− load, which causes pronounced alkalosis in AC6-deficient mice. However, the phenotype of AC6-deficient mice appears much more complex, involving systemic effects associated with increased energy expenditure. These observations remind us that there is much to be learned about the intricate signaling pathways involved in renal control of acid-base balance and the complex ramifications of acid-base regulation.
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September 2018
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A scanning electron micrograph (digitally altered and colourized, 4000× magnification) depicting a mesenchymal stem cell (orange) encapsulated in a self-assembling peptide hydrogel. In volume 132, issue 17 of Clinical Science, McFetridge et al. discuss the use of hydrogel materials to unlock the potential of stem cell therapy to treat chronic kidney disease. This image was provided by the authors and produced in collaboration with Dr Simon Crawford at the Ramaciotti Centre for Cryo-Electron Microscopy, and the Monash Teaching Resource Support Unit.
Commentary|
September 14 2018
Adenylyl cyclase 6 in acid-base balance – adding complexity
Jakob Voelkl;
1Department of Internal Medicine and Cardiology, Charité – Universitätsmedizin Berlin, Augustenburgerplatz 1, Berlin 13353, Germany
2DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Hessische Str. 3-4, Berlin 10115, Germany
Correspondence: Jakob Voelkl ([email protected])
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Florian Lang
Florian Lang
3Department of Physiology I, Eberhard-Karls University, Wilhelmstr. 56, Tübingen 72076, Germany
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Publisher: Portland Press Ltd
Received:
August 02 2018
Revision Received:
August 14 2018
Accepted:
August 16 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (17): 1995–1997.
Article history
Received:
August 02 2018
Revision Received:
August 14 2018
Accepted:
August 16 2018
Connected Content
This is a commentary on:
Adenylyl cyclase 6 is required for maintaining acid–base homeostasis
Citation
Jakob Voelkl, Florian Lang; Adenylyl cyclase 6 in acid-base balance – adding complexity. Clin Sci (Lond) 14 September 2018; 132 (17): 1995–1997. doi: https://doi.org/10.1042/CS20180572
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