Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism, and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3+ and CD8+) populations compared with lean or obese controls. Further, local interleukin (IL) 1β and IL 1 receptor antagonist (il1rn) cmRNA were increased in placenta of VSG dams. Placental barrier function was also affected, with increased transplacental permeability to small molecules, increased matrix metalloproteinase 9 expression, and increased apoptosis in VSG. Furthermore, we identified increased placental mTOR signaling that may contribute to preserving the body weight of the fetuses during gestation. These changes occurred in the absence of a macronutrient deficit or gestational hypertension in the VSG dams. In summary, previous VSG in dams may contribute to fetal demise by affecting maternal immune system activity and compromise placental integrity.
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Oleic-acid-treated HepG2 cells immunostained for PGC-1α (PPARγ co-activator-1 α). In Clinical Science volume 132, issue 1, the results of work by Bernardi et al. include reporting that the protein TRAIL (TNF-related apoptosis inducing ligand) increases the expression of PGC-1α in HepG2 cells cultured with oleic acid. Overall, the article points to a potential therapeutic role for TRAIL against impaired glucose tolerance and non-alcoholic fatty liver disease; for details see pages 69–83.
Research Article|
January 25 2018
Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development
Redin A. Spann;
Redin A. Spann
1Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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William J. Lawson;
William J. Lawson
1Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Gene L. Bidwell, III;
Gene L. Bidwell, III
2Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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C. Austin Zamarripa;
C. Austin Zamarripa
3Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Rodrigo O. Maranon;
Rodrigo O. Maranon
4Department of Nephrology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
9Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Sibali Bandyopadhyay;
Sibali Bandyopadhyay
5Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Erin R. Taylor;
Erin R. Taylor
6Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Jane F. Reckelhoff;
Jane F. Reckelhoff
7Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
9Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
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Michael R. Garrett;
8Department of Pharmacology, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
9Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
11Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A
Correspondence: Bernadette E. Grayson ([email protected])
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Bernadette E. Grayson
1Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
9Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
10Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
11Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A
Correspondence: Bernadette E. Grayson ([email protected])
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Publisher: Portland Press Ltd
Received:
October 04 2017
Revision Received:
November 10 2017
Accepted:
November 21 2017
Accepted Manuscript online:
November 22 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (2): 295–312.
Article history
Received:
October 04 2017
Revision Received:
November 10 2017
Accepted:
November 21 2017
Accepted Manuscript online:
November 22 2017
Citation
Redin A. Spann, William J. Lawson, Gene L. Bidwell, C. Austin Zamarripa, Rodrigo O. Maranon, Sibali Bandyopadhyay, Erin R. Taylor, Jane F. Reckelhoff, Michael R. Garrett, Bernadette E. Grayson; Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development. Clin Sci (Lond) 31 January 2018; 132 (2): 295–312. doi: https://doi.org/10.1042/CS20171416
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