Increased production of reactive oxygen species (ROS) and inflammation are major contributors to the development and progression of diabetes-associated erectile dysfunction (DMED). As an endogenous antioxidant and anti-inflammatory factor, the potential implication of pigment epithelium-derived factor (PEDF) in DMED has not been revealed. To assess the potential antioxidant and anti-inflammatory functions of PEDF in DMED, we first demonstrated that PEDF was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer of control virus (Ad-GFP) was intracavernously administered at 2 weeks after diabetic onset. After 6 weeks of treatment, we found that administration of Ad-PEDF could significantly increase erectile response to cavernosal nerve stimulation in the diabetic rats by restoring the endothelial NO synthase (eNOS), P-eNOS, and neuronal NO synthase (nNOS) protein levels to the standard levels represented in normal rats and by suppressing the levels of tumor necrosis factor-α (TNF-α) and oxidative stress. In conclusion, the present data indicated that the antioxidant and anti-inflammatory potential of PEDF plays important role in restoring erectile function by the inhibition of oxidative stress and TNF-α production.
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October 2018
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In this issue, Wohlfahrtova et al. report on the link between early isolated v-lesion (eIV) and rejection of kidney allografts. The cover image is a Circos plot that depicts the association between the 15 most signifi cant up-regulated genes between TCMRV (T cell-mediated vascular rejection) and eIV, and signifi cantly enriched pathways and GO terms that play a role in the immune response. For further details, see pages 2269–2284 .
Research Article|
October 19 2018
Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats
Hongjie Qiao;
Hongjie Qiao
*
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Yuanyuan Zhang;
Yuanyuan Zhang
*
2Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, U.S.A.
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Wenwen Lin;
Wenwen Lin
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Yu-Feng Wang;
Yu-Feng Wang
3Department of Physiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China
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Cristina M. Furdui;
Cristina M. Furdui
4Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, U.S.A.
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Qiuling Jiang;
Qiuling Jiang
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Xiao Li;
Xiao Li
†
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Ting Long;
Ting Long
†
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Yunguang Wang;
Yunguang Wang
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
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Da-nian Qin
1Department of Physiology, Shantou University Medical College, Shantou 515041, China
Correspondence: Da-nian Qin ([email protected])
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Publisher: Portland Press Ltd
Received:
March 02 2018
Revision Received:
August 29 2018
Accepted:
September 18 2018
Accepted Manuscript online:
September 19 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (20): 2175–2188.
Article history
Received:
March 02 2018
Revision Received:
August 29 2018
Accepted:
September 18 2018
Accepted Manuscript online:
September 19 2018
Citation
Hongjie Qiao, Yuanyuan Zhang, Wenwen Lin, Yu-Feng Wang, Cristina M. Furdui, Qiuling Jiang, Xiao Li, Ting Long, Yunguang Wang, Da-nian Qin; Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats. Clin Sci (Lond) 31 October 2018; 132 (20): 2175–2188. doi: https://doi.org/10.1042/CS20180192
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