Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation, leading to endothelial dysfunction. In the present study, we investigated the associations between habitual sodium intake and RAAS blockade on endothelial function by measuring circulating microparticles (MPs) in individuals with T2D. Methods: We conducted a prospective, cross-sectional study in 74 individuals with T2D. Habitual dietary sodium intake was estimated by using the mean of three corrected 24-h urine sodium excretion measurements (24hUNa). MP subtypes in platelet-free plasma were quantitated using flow cytometry. Results: No associations between 24hUNa with levels of endothelial MPs were observed. Instead, a trend toward higher diabetes related CD36+/CD235a+ MP levels was associated with lower 24hUNa (rho = −0.23, P=0.05). When stratified according to tertiles of 24hUNa, platelet-derived CD42b+/CD41+ and CD42+/CD41+/Annexin V+ MPs were higher in the lowest tertile (24hUNa < 157 mmol/24 h) (P=0.02 respectively). Despite RAAS blockade being associated with lower levels of most MP subsets, it was not associated with lower MPs, in the setting of low sodium intake. Conclusion: Lower sodium intake is associated with higher circulating procoagulant MPs, but not with evidence of endothelial dysfunction in individuals with T2D.
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October 2018
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In this issue, Wohlfahrtova et al. report on the link between early isolated v-lesion (eIV) and rejection of kidney allografts. The cover image is a Circos plot that depicts the association between the 15 most signifi cant up-regulated genes between TCMRV (T cell-mediated vascular rejection) and eIV, and signifi cantly enriched pathways and GO terms that play a role in the immune response. For further details, see pages 2269–2284 .
Research Article|
October 23 2018
The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes
Sara Baqar;
Sara Baqar
1Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
2Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia
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Dorothy Liu;
Dorothy Liu
3Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia
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Lisa F. Lincz;
Lisa F. Lincz
4Hunter Haematology Research Group, Calvary Mater Newcastle Hospital, Waratah, New South Wales, Australia
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Yee Wen Kong;
Yee Wen Kong
3Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia
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George Jerums;
George Jerums
1Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
2Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia
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Elif I. Ekinci
1Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
2Department of Medicine (Austin Health), The University of Melbourne, Victoria, Australia
Correspondence: Elif I. Ekinci ([email protected])
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Publisher: Portland Press Ltd
Received:
June 05 2018
Revision Received:
September 12 2018
Accepted:
September 24 2018
Accepted Manuscript online:
September 24 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Article history
Received:
June 05 2018
Revision Received:
September 12 2018
Accepted:
September 24 2018
Accepted Manuscript online:
September 24 2018
Citation
Sara Baqar, Dorothy Liu, Lisa F. Lincz, Yee Wen Kong, George Jerums, Elif I. Ekinci; The relationship between habitual dietary sodium intake and RAAS blockade on circulating microparticle levels in type two diabetes. Clin Sci (Lond) 31 October 2018; 132 (20): 2207–2220. doi: https://doi.org/10.1042/CS20180472
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