The cerebrovasculature is a multicellular structure with varying rheological and permeability properties. The outer wall of the brain capillary endothelium is enclosed by pericytes and astrocyte end feet, anatomically assembled to guarantee barrier functions. We, here, focus on the pericyte modifications occurring in disease conditions, reviewing evidence supporting the interplay amongst pericytes, the endothelium, and glial cells in health and pathology. Deconstruction and reactivity of pericytes and glial cells around the capillary endothelium occur in response to traumatic brain injury, epilepsy, and neurodegenerative disorders, impacting vascular permeability and participating in neuroinflammation. As this represents a growing field of research, addressing the multicellular reorganization occurring at the outer wall of the blood-brain barrier (BBB) in response to an acute insult or a chronic disease could disclose novel disease mechanisms and therapeutic targets.
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February 2018
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Cover Image
Cover Image
A representative image of an airway from a mouse sensitized and challenged with an allergen. The histological image was captured 24 hours after allergen exposure at which point airway hyperresponsiveness persists without any discernible change to wall structure. In Clinical Science volume 132, issue 3, Wang et al. report on the effects of airway remodelling and allergy on airway responsiveness; for details see pages 327–338. Image kindly provided by Kimberley C.W. Wang (The University of Western Australia).
Review Article|
February 08 2018
The pericyte–glia interface at the blood–brain barrier
Patrizia Giannoni;
Patrizia Giannoni
1Chrome Unit, EA7352, University of Nimes, France
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Jerome Badaut;
Jerome Badaut
2Laboratory of Brain Molecular Imaging, CNRS UMR5287, University of Bordeaux, France
3Basic Science Departments, Loma Linda University School of Medicine, CA, U.S.A.
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Cyril Dargazanli;
Cyril Dargazanli
4Neuroradiology, University Hospital, Montpellier, France
5Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
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Alexis Fayd’Herbe De Maudave;
Alexis Fayd’Herbe De Maudave
5Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
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Wendy Klement;
Wendy Klement
5Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
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Vincent Costalat;
Vincent Costalat
4Neuroradiology, University Hospital, Montpellier, France
5Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
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Nicola Marchi
5Laboratory of Cerebrovascular Mechanisms of Brain Disorders, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France
Correspondence: Nicola Marchi ([email protected])
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Publisher: Portland Press Ltd
Received:
December 15 2017
Revision Received:
January 04 2018
Accepted:
January 04 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (3): 361–374.
Article history
Received:
December 15 2017
Revision Received:
January 04 2018
Accepted:
January 04 2018
Citation
Patrizia Giannoni, Jerome Badaut, Cyril Dargazanli, Alexis Fayd’Herbe De Maudave, Wendy Klement, Vincent Costalat, Nicola Marchi; The pericyte–glia interface at the blood–brain barrier. Clin Sci (Lond) 14 February 2018; 132 (3): 361–374. doi: https://doi.org/10.1042/CS20171634
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