The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed a positive association between nephrolithiasis and CVDs. Based on preclinical and clinical evidences, this review discusses: (i) stone forming risk factors, crystal nucleation, aggregation, injury-induced crystal retention, and stone formation, (ii) CVD risk factors such as dyslipidemia, perturbation of gut microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described.
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Cover ImageCD31 immunofluorescence staining of a mesenteric window taken from a rat with liver cirrhosis. In Clinical Science volume 132, Issue 6, Huang et al. use CD31 immunofluorescence staining to show an increased density of the vascular network in the mesenteric window of rats with bile duct ligation-induced liver cirrhosis. Vascular network density is usually low in non-cirrhotic condition, indicating that mesenteric angiogenesis takes place in liver cirrhosis; for details see pages 669–683.Close Modal
Review Article| March 20 2018
Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases
Asokan Devarajan *
1Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, U.S.A.
Correspondence: Asokan Devarajan (email@example.com)
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Clin Sci (Lond) (2018) 132 (6): 615–626.
November 28 2017
January 10 2018
January 12 2018
Asokan Devarajan; Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases. Clin Sci (Lond) 30 March 2018; 132 (6): 615–626. doi: https://doi.org/10.1042/CS20171574
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