The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease. However, links amongst gut pathology, microbial ecology, and blood pressure remain elusive. In a recent issue of Clinical Science (vol. 132, issue 6, 701-718), Kim et al. demonstrate a crucial link between gut microbiota and bacterial metabolites such as butyrate, gut leakiness, and hypertension.
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April 2018
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A representation of the intestinal microflora. In Clinical Science volume 132 (issue 7), Rajani and Jia review recent research on the effect of bacterial metabolites on host metabolism (microbiota-host co-metabolism) associated with conditions such as obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (pages 791-811). Then, in issue 8, Lezutekong et al. (pages 901-904) provide a commentary on a recent research by Kim et al. in Clinical Science that demonstrates a crucial link between gut microbiota and bacterial metabolites such as butyrate, gut leakiness, and hypertension. These and other articles from the journal are featured in a themed collection on the topic of the microbiome and chronic disease.
Commentary|
April 30 2018
Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease
Judith N. Lezutekong;
Judith N. Lezutekong
1Department of Physiology, University of Alberta, Edmonton, Alberta, Canada
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Anish Nikhanj;
Anish Nikhanj
2Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
3Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
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Gavin Y. Oudit
2Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
3Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Correspondence: Gavin Y. Oudit ([email protected])
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Publisher: Portland Press Ltd
Received:
March 23 2018
Revision Received:
April 11 2018
Accepted:
April 13 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (8): 901–904.
Article history
Received:
March 23 2018
Revision Received:
April 11 2018
Accepted:
April 13 2018
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Citation
Judith N. Lezutekong, Anish Nikhanj, Gavin Y. Oudit; Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease. Clin Sci (Lond) 30 April 2018; 132 (8): 901–904. doi: https://doi.org/10.1042/CS20180172
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