There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death worldwide. Despite the benefits of exercise, the intricacies of their underlying molecular mechanisms remain largely unknown. Non-coding RNAs (ncRNAs) have been recognized as a major regulatory network governing gene expression in several physiological processes and appeared as pivotal modulators in a myriad of cardiovascular processes under physiological and pathological conditions. However, little is known about ncRNA expression and role in response to exercise. Revealing the molecular components and mechanisms of the link between exercise and health outcomes will catalyse discoveries of new biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed.
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May 2018
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Depiction of a macrophage. In issue 9 of Clinical science, Liu et al. discuss the role of miRNAs in alveolar macrophage activation; for details see pages 943–958.
Review Article|
May 21 2018
Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system
Clarissa P.C. Gomes;
Clarissa P.C. Gomes
1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg
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David de Gonzalo-Calvo;
David de Gonzalo-Calvo
2Institute of Biomedical Research of Barcelona (IIBB) – Spanish National Research Council (CSIC), Barcelona, Spain
3Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain
4CIBERCV, Institute of Health Carlos III, Madrid, Spain
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Rocio Toro;
Rocio Toro
5University of Cádiz and Institute of Biomedical Research Cádiz (INIBICA), Cádiz, Spain
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Tiago Fernandes;
Tiago Fernandes
6Laboratory of Biochemistry and Molecular Biology of the Exercise, School of Physical Education and Sport, University of Sao Paulo, Brazil
7Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, U.S.A.
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Daniel Theisen;
Daniel Theisen
8Sports Medicine Research Laboratory, Luxembourg Institute of Health, Luxembourg, Luxembourg
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Da-Zhi Wang;
Da-Zhi Wang
7Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, U.S.A.
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Yvan Devaux;
1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg
Correspondence: Yvan Devaux ([email protected])
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on behalf of the Cardiolinc™ network
on behalf of the Cardiolinc™ network
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Publisher: Portland Press Ltd
Received:
February 05 2018
Revision Received:
April 12 2018
Accepted:
April 16 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (9): 925–942.
Article history
Received:
February 05 2018
Revision Received:
April 12 2018
Accepted:
April 16 2018
Citation
Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network; Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system. Clin Sci (Lond) 16 May 2018; 132 (9): 925–942. doi: https://doi.org/10.1042/CS20171463
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