Clinical Science was originally established as the journal Heart in 1909 by Sir Thomas Lewis and Sir James Mackenzie. Heart was an influential journal publishing cardiovascular research and was renamed Clinical Science in 1933 to attract broader research interests. Nevertheless, cardiovascular research contributions remain a foundational part of the journal to this day. This editorial provides historical perspective on the journal’s cardiovascular origins and includes data related to cardiovascular publications from the past decade. Clinical Science is committed to publishing leading cardiovascular research from the field and looks forward to receiving your submission.