Lactylation, a post-translational modification, has been linked to gene transcription regulation through epigenetic modulation in various pathophysiological processes. The lactylation regulatory proteins, known as writers, erasers, and readers, govern their dynamics by adding, removing, and recognizing lactyl groups on proteins. Macrophages, as cells of the immune system, maintain homeostasis, responding dynamically to diverse internal and external stimuli. Emerging researches unveil that lactylation, through inducing macrophage activation and polarization, affects their functionality in pathological conditions such as inflammation, tumor microenvironment, and fibrosis. Evidence progressively indicates that lactate-driven alterations in lactylation levels within macrophages can influence the pathogenesis of numerous diseases. This review aims to systematically summarize the research progress of lactylation in macrophages, explore its functions and mechanisms by which lactylation contributes to the pathology of different disease phenotypes, and propose future research directions along with potential diagnostic and therapeutic strategies.
Skip Nav Destination
Article navigation
Review Article|
January 13 2025
Insight into the roles of lactylation in macrophages: functions and clinical implications
Min Shu;
Min Shu
(Validation, Visualization, Methodology, Writing - original draft, Project administration, Writing - review & editing)
1School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road 1, Jingzhou, Hubei 434023, China
Search for other works by this author on:
Dingci Lu;
Dingci Lu
(Resources, Data curation, Software, Formal analysis)
1School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road 1, Jingzhou, Hubei 434023, China
Search for other works by this author on:
Ziyi Zhu;
Ziyi Zhu
(Funding acquisition, Validation, Investigation)
1School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road 1, Jingzhou, Hubei 434023, China
Search for other works by this author on:
Fei Yang;
Fei Yang
(Validation, Investigation)
1School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road 1, Jingzhou, Hubei 434023, China
Search for other works by this author on:
Zhaowu Ma
1School of Basic Medicine, Health Science Center, Yangtze University, Nanhuan Road 1, Jingzhou, Hubei 434023, China
Correspondence: Zhaowu Ma ([email protected])
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 30 2024
Revision Received:
January 03 2025
Accepted:
January 13 2025
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2025 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.
2025
Clin Sci (Lond) (2025) 139 (02): 151–169.
Article history
Received:
October 30 2024
Revision Received:
January 03 2025
Accepted:
January 13 2025
Citation
Min Shu, Dingci Lu, Ziyi Zhu, Fei Yang, Zhaowu Ma; Insight into the roles of lactylation in macrophages: functions and clinical implications. Clin Sci (Lond) 28 January 2025; 139 (02): 151–169. doi: https://doi.org/10.1042/CS20242737
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
219
Views
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |