1. The effect of propranolol on adrenaline- and insulin-induced hypophosphataemia was studied in man.
2. β-Adrenergic blockade with propranolol almost completely abolished and significantly inhibited adrenaline- and insulin-induced hypophosphataemia respectively; in addition, the drug clearly prevented the normally observed rise in plasma lactate, while causing only a slight change in blood glucose levels.
3. It is suggested that the fall in blood phosphate values induced by adrenaline and, in part, that caused by insulin, is mediated by β-adrenergic receptors.
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© 1970 The Biochemical Society and the Medical Research Society
1970
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